Methorphan
Category:Use dmy dates from March 2026
Category:Articles with short descriptionCategory:Short description is different from WikidataLevomethorphan (L), dextromethorphan (R) | |||
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| Formula | C18H25NO | ||
| Molar mass | 271.404 g·mol−1 | ||
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Methorphan is an opioid drug that occurs in two isomeric forms, each with differing pharmacology and effects:
- Dextromethorphan – An over-the-counter cough suppressant, as well as dissociative hallucinogen.
- Levomethorphan – A potent opioid analgesic that was never clinically developed; a prodrug of the powerful opioid agonist analgesic levorphanol (Levo-Dromoran).
Racemethorphan is the racemic mixture of both of these stereoisomers.[2] It is listed under the Single Convention on Narcotic Drugs 1961 and is therefore listed in the United States as a Controlled Substance, specifically as a Narcotic in Schedule II with an ACSCN of 9732 and an annual aggregate manufacturing quota of 3 grams in 2014.[3][4] The salts in use are the hydrobromide (free base conversion ratio 0.770) and the tartrate (0.644).
See also
References
- ↑ Anvisa (31 March 2023). "RDC Nº 784 - Listas de Substâncias Entorpecentes, Psicotrópicas, Precursoras e Outras sob Controle Especial" [Collegiate Board Resolution No. 784 - Lists of Narcotic, Psychotropic, Precursor, and Other Substances under Special Control] (in Brazilian Portuguese). Diário Oficial da União (published 4 April 2023). Archived from the original on 3 August 2023. Retrieved 16 August 2023.Category:CS1 Brazilian Portuguese-language sources (pt-br)
- ↑ Aumatell A, Wells RJ (December 1993). "Chiral differentiation of the optical isomers of racemethorphan and racemorphan in urine by capillary zone electrophoresis". Journal of Chromatographic Science. 31 (12): 502–8. doi:10.1093/chromsci/31.12.502. PMID 8120122.
- ↑ "Conversion Factors for Controlled Substances". www.deadiversion.usdoj.gov. Archived from the original on 2 March 2016. Retrieved 27 February 2016.
- ↑ Nordegren T (2002). "Racemethorphan". The A-Z Encyclopedia of Alcohol and Drug Abuse. Parkland, Fla.: Brown Walker Press. pp. 548–549. ISBN 978-1-58112-404-0.
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