Terodiline

Category:Articles with short descriptionCategory:Short description is different from Wikidata
Terodiline
Clinical data
ATC code
Identifiers
  • N-tert-butyl-4,4-di(phenyl)butan-2-amine
CAS Number
PubChem CID
ChemSpider
UNII
ChEMBL
CompTox Dashboard (EPA)
Chemical and physical data
FormulaC20H27N
Molar mass281.443 g·mol−1
3D model (JSmol)
  • c1ccccc1C(c2ccccc2)CC(NC(C)(C)C)C
  • InChI=1S/C20H27N/c1-16(21-20(2,3)4)15-19(17-11-7-5-8-12-17)18-13-9-6-10-14-18/h5-14,16,19,21H,15H2,1-4H3 checkY
  • Key:UISARWKNNNHPGI-UHFFFAOYSA-N checkY
  (verify)
Category:Chemical pages without DrugBank identifier#*Category:Articles without KEGG source#*Category:Drugs with no legal status

Terodiline is a drug used in urology as an antispasmodic.

It relaxes the smooth muscle and used to reduce bladder tone in treatment of urinary frequency and incontinence. Muscle relaxation caused by terodiline, is probably due to its anticholinergic and calcium antagonist activity.

However, it also blocks Kv11.1 ion channels and consequently can pose a risk for torsades de pointes. This cardiotoxicity is concentration dependent.[1]

References

  1. ↑ Thomas SH, Higham PD, Hartigan-Go K, Kamali F, Wood P, Campbell RW, Ford GA (1995). "Concentration dependent cardiotoxicity of terodiline in patients treated for urinary incontinence". Br Heart J. 74 (1): 53–6. doi:10.1136/hrt.74.1.53. PMC 483946. PMID 7662454.
Category:Secondary amines Category:HERG blocker Category:Muscarinic antagonists Category:Tert-butyl compounds


Category:All stub articles Category:Articles with short description Category:Articles without KEGG source Category:Chemical pages without DrugBank identifier Category:Drugs with no legal status Category:Genito-urinary system drug stubs Category:HERG blocker Category:Muscarinic antagonists Category:Secondary amines Category:Short description is different from Wikidata Category:Short description matches Wikidata Category:Tert-butyl compounds