Timiperone

Category:Articles with short descriptionCategory:Short description is different from Wikidata
Timiperone
Clinical data
Trade namesTolopelon
AHFS/Drugs.comInternational Drug Names
Routes of
administration		By mouth
ATC code
Legal status
Legal status
Identifiers
  • 1-(4-fluorophenyl)-4-[4-(2-sulfanylidene-3H-benzimidazol-1-yl)piperidin-1-yl]butan-1-one
CAS Number
PubChem CID
ChemSpider
UNII
KEGG
ChEMBL
CompTox Dashboard (EPA)
ECHA InfoCard100.055.328 Edit this at WikidataCategory:ECHA InfoCard ID from Wikidata#*
Chemical and physical data
FormulaC22H24FN3OS
Molar mass397.51 g·mol−1
3D model (JSmol)
  • C1CN(CCC1N2C3=CC=CC=C3NC2=S)CCCC(=O)C4=CC=C(C=C4)F
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Category:Chemical pages without DrugBank identifier#*Category:Drugboxes which contain changes to verified fieldsCategory:Drugboxes which contain changes to watched fields

Timiperone, sold under the brand name Tolopelon, is a typical antipsychotic of the butyrophenone class which is marketed in Japan for the treatment of schizophrenia.[1][2][3][4] It is similar in chemical structure to benperidol, but has a thiourea group instead of a urea group. It acts as an antagonist for the D2 and 5-HT2A receptors.[4]

References

  1. ↑ Index Nominum 2000: International Drug Directory. Taylor & Francis. 2000. pp. 1030–. ISBN 978-3-88763-075-1.
  2. ↑ Yamasaki T, Kojima H, Tanaka M, Aibara S, Hirohashi M, Kasai Y, et al. (1981). "Pharmacological studies on timiperone, a new neuroleptic drug Part II: General pharmacological properties". Arzneimittel-Forschung. 31 (4): 707–15. PMID 6113834.
  3. ↑ Tanaka M, Kojima H, Akashi A (November 1985). "Effect of timiperone, a new antipsychotic drug, on the sleep-wakefulness cycle in cats". Japanese Journal of Pharmacology. 39 (3): 391–4. doi:10.1254/jjp.39.391. PMID 2869168.
  4. 1 2 Miyamoto S (2010). "Timiperone". In Stolerman IP (ed.). Encyclopedia of Psychopharmacology. Berlin, Heidelberg: Springer. p. 1323. doi:10.1007/978-3-540-68706-1_1902. ISBN 978-3-540-68706-1. Retrieved 2022-03-11.
Category:Butyrophenone antipsychotics Category:4-Fluorophenyl compounds Category:Piperidinylbenzimidazolines Category:Thioureas Category:Typical antipsychotics
Category:4-Fluorophenyl compounds Category:All stub articles Category:Articles with changed ChemSpider identifier Category:Articles with changed InChI identifier Category:Articles with short description Category:Butyrophenone antipsychotics Category:Chemical pages without DrugBank identifier Category:Drugboxes which contain changes to verified fields Category:Drugboxes which contain changes to watched fields Category:Drugs not assigned an ATC code Category:Drugs with non-standard legal status Category:ECHA InfoCard ID from Wikidata Category:Nervous system drug stubs Category:Piperidinylbenzimidazolines Category:Short description is different from Wikidata Category:Thioureas Category:Typical antipsychotics